AMPK pathway
Investigated for AMPK-activation signalling in metabolic models. AMPK is the cellular energy sensor, and the same pathway exercise activates.
RP-HPLC · 214nm
99%+ HPLCPASS
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.61 g/mol
- CAS / identifier
- 1627580-64-6
- Appearance
- White lyophilised powder
- Solubility
- Soluble in bacteriostatic water
- Storage
- -20°C long term, 2-8°C in use
- Purity
- 99%+ by RP-HPLC, 214 nm
- Identity
- Confirmed (LC-MS)
- Ships from
- United States
Lyophilised powder · 99%+ documented HPLC
Ships from USAView COA
MOTS-C Peptide
Mitochondrial-derived peptide studied in metabolic-homeostasis and cellular-aging models.
$64.99per 10mg vial
Vial size
10mg$64.99$6.50/mg
1
Purity 99%+RP-HPLC documented
Identity conformsLC-MS verified
- Ships from the US
- Discreet packaging
- Free shipping over $250
- 16aa
- Length of the peptide. Encoded in mitochondrial DNA rather than in the cell nucleus, which is unusual and is much of why it is studied. Lee, Cell Metab 2015
- 2015
- Year it was identified and described as a mitochondrial-derived peptide. Cell Metab 2015
- AMPK
- The cellular energy sensor through which the reported effects were traced. The same pathway exercise activates. Cell Metab 2015
- Muscle
- Main tissue where the activity was located in the source study, which is why it is studied in skeletal-muscle models. Cell Metab 2015
Figures are structural data from our specification and certificates, or are drawn from published third-party literature about the compound, and are provided for orientation only. Nothing here is a claim about what this material does. Supplied for laboratory research use only.
01About this compound
What MOTS-C is
MOTS-c is a sixteen-residue peptide encoded inside mitochondrial DNA rather than in the cell nucleus, which is unusual and is much of why it is studied. Research examines how the body handles blood sugar and stores fat, and why a peptide from the cell's energy compartment appears to influence metabolism throughout the body.
- Sequence
- MRWQEMGYIFYPRKLR
- CAS
- 1627580-64-6
- Formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- Residues
- 16
- Presentation
- 10mg vials
Sequence
- M
- R
- W
- Q
- E
- M
- G
- Y
- I
- F
- Y
- P
- R
- K
- L
- R
BACKBONE IMPRESSION · NOT A STRUCTURAL MODEL
Atomic composition
305atoms
- 101
- 152
- 28
- 22
- 2
C101H152N28O22S2 · composition, not conformation
02MechanismHow MOTS-C
How MOTS-C
has been studied.
Signalling pathways examined in preclinical models. Descriptive of published research directions, not claims of effect.
Mitochondrial models
Explored for mitochondrial-function endpoints in cellular models, and for how a mitochondrially encoded peptide signals to the nucleus.
Metabolic homeostasis
Studied in glucose-regulation models, where the reported activity was located principally in skeletal muscle.
03Uses & applications
What MOTS-C is researched for
Blood-sugar handling
Preclinical, Cell Metab 2015
Insulin resistance from a high-fat diet did not develop in the treated group.
Fat storage
Preclinical, Cell Metab 2015
Less fat accumulated, particularly the deeper fat around the organs.
How it works
Mechanism, Cell Metab 2015
Traced to increased fat burning through the AMPK energy pathway.
04Class comparison
How it compares in its class
Reference class characteristics for orientation. Half-life figures are typical literature values, not lot measurements.
| Compound | Receptor class | Typical half-life | Note |
|---|---|---|---|
| MOTS-C | Mitochondrial-derived peptide | Short | AMPK activation |
| NAD+ | Redox coenzyme | Short | Sirtuin substrate |
| Tesamorelin | GHRH analogue | Short | Visceral adipose models |
| Ipamorelin | GH secretagogue | Short | Selective GH release |
05Research history
Class research timeline
Milestones in the study of this compound class.
- 2015
Identified by Lee et al. as a mitochondrial-derived peptide promoting metabolic homeostasis in mouse models.
- 2016
Population studies linked sequence variants, notably R150Q, to longevity phenotypes.
- 2021
Reported as an exercise-induced regulator of age-dependent physical decline.
- 2022
Characterised as an exercise-mimetic mitochondrial signal.
06Documentation
Certificates of analysis
Every lot is documented by an independent laboratory. The newest lot appears first.
| Lot | Reported | Size | HPLC | Laboratory | Certificate |
|---|---|---|---|---|---|
| MOT10-052026-4 | 14 May 2026 | 10mg | 99.76% | Freedom Diagnostics | View |
| MOT10-052026-1 | 14 May 2026 | 10mg | 99.59% | Freedom Diagnostics | View |
| MOT10-032026-H | 12 Mar 2026 | 10mg | 99.763% | Freedom Diagnostics | View |
Newest lot
99.76%
HPLC purity
- Lot
- MOT10-052026-4
- Certificate reported
- 14 May 2026
- Released to sale
- 17 Jul 2026
- Size
- 10mg
- Identity
- Confirmed (LC-MS)
- Content
- 12.07mg
- Appearance
- White lyophilised powder
- Endotoxin
- Pass, both replicates
- Laboratory
- Freedom Diagnostics
- Accession
- 2605130124
- Search code
- Whol2605130124
The signed PDF is the full certificate. The accession and search code above resolve the same record at the laboratory.
07Third-party verifiedIndependently tested.
Independently tested.
Verifiably pure.
- PASS
HPLC purity
RP-HPLC, 214 nm
- CONFIRMED
Identity
LC-MS
Certificate of analysis
PASSLot MOT10-052026-4
RP-HPLC · 214nm14 May 2026
- HPLC purity
- 99.76%
- Identity
- Confirmed (LC-MS)
- Laboratory
- Freedom Diagnostics
- Net content
- 12.07mg
08Full specification
Every field on the label
- Sequence
- MRWQEMGYIFYPRKLR
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.61 g/mol
- CAS / identifier
- 1627580-64-6
- Quantity per vial
- 10 mg
- Purity
- 99.76% by RP-HPLC, 214 nm
- Identity
- Confirmed (LC-MS)
- Appearance
- White lyophilised powder
- Solubility
- Soluble in bacteriostatic water
- Storage
- -20°C long term, 2-8°C in use
- Ships from
- United States
- Lot
- MOT10-052026-4
- Assay date
- 14 May 2026
This material is supplied as a reference standard for in-vitro laboratory research only. It has not been evaluated by the FDA, is not a drug, and is not intended for human or veterinary use. Handling should follow your institution's chemical hygiene plan, including appropriate PPE and documented disposal.
Every lot is documented at 99%+ by RP-HPLC with identity confirmed by LC-MS, run by an independent laboratory. Released lots have measured between 99.59% and 99.763%; the figure for the lot you receive is in the certificate table above.
Yes. Every lot ships with its own signed certificate, and every certificate is published here, including for lots no longer in stock.
10mg vials.
MRWQEMGYIFYPRKLR. Sixteen residues, encoded in the 12S rRNA region of mitochondrial DNA rather than in the nucleus.
Because it established that mitochondria can produce bioactive peptides that signal to the rest of the cell, rather than acting purely as energy machinery. That finding is what opened the field this compound belongs to.
Store the sealed vial at −20°C for long-term stability and 2–8°C for short-term handling. Protect from light and avoid repeated freeze-thaw cycles. Compound-specific stability data is printed on the certificate of analysis supplied with the lot.
10Cited sources
Published literature
Independent published research relating to this compound. Listed for reference; Serviam Bio Labs is not affiliated with these authors and makes no claims based on their findings.
- [1]
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis
Lee C et al. · 2015 · Cell Metabolism
metabolic - [2]
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline
Reynolds JC et al. · 2021 · Nature Communications
exercise - [3]
A mitochondrial-derived peptide variant and longevity in an elderly Japanese population
Zempo H et al. · 2016 · Aging
longevity
Research encyclopedia
Read the monographThe MOTS-C monograph
The full reference entry: molecular data, the mechanisms described in the literature, what the research covers, the specification and the papers behind it.
Research library
The evidence behind this page
For laboratory research use only. All compounds listed on this site are sold strictly as reference materials for in-vitro laboratory research conducted by qualified professionals. They are not drugs, foods, cosmetics, or medical devices. They are not intended for human or veterinary consumption, therapeutic use, diagnostic application, or any in-vivo use whatsoever. These statements have not been evaluated by the Food and Drug Administration. By purchasing, you affirm that you are a qualified researcher and that you will comply with all applicable institutional, local, state and federal regulations governing the handling of research chemicals.