Lyophilised powder · 99%+ documented HPLC
Core redox coenzyme central to cellular energy metabolism and sirtuin/PARP signalling. Not a peptide.
$99.99per 1000mg vial
Figures are structural data from our specification and certificates, or are drawn from published third-party literature about the compound, and are provided for orientation only. Nothing here is a claim about what this material does. Supplied for laboratory research use only.
NAD+ is not a peptide. It is a coenzyme every living cell carries, and it does two jobs at once: it shuttles electrons through energy metabolism, and it is consumed as a substrate by the sirtuin and PARP enzyme families. That second role is why a molecule catalogued since 1906 became a longevity research subject a century later, because it is the point where a cell's energy state and its ageing machinery meet the same molecule.
C21H27N7O14P2 · composition, not conformation
Signalling pathways examined in preclinical models. Descriptive of published research directions, not claims of effect.
Serves as substrate for sirtuins in cellular-aging research models. All seven mammalian sirtuins require it, and unlike an ordinary cofactor it is consumed rather than recycled, which is why availability itself becomes the variable under study.
The central NAD+/NADH couple, studied in energy-metabolism endpoints. It carries electrons through glycolysis, the citric acid cycle and oxidative phosphorylation, so the ratio between its two forms reports on the cell's energy state.
Consumed by PARP enzymes during DNA damage response, which puts repair activity and sirtuin activity in competition for the same finite pool. That competition is a recurring theme in the ageing literature.
Provides the mechanism translating a cell's energy state into ageing and lifespan control.
The sirtuin family cannot function without it.
Preclinical work on raising its levels is now moving into clinical study.
Reference class characteristics for orientation. Half-life figures are typical literature values, not lot measurements.
| Compound | Receptor class | Typical half-life | Note |
|---|---|---|---|
| NAD+ | Redox coenzyme | Short | Sirtuin and PARP substrate |
| MOTS-C | Mitochondrial-derived peptide | Short | AMPK activation |
| GHK-Cu | Copper-binding tripeptide | Short | Gene-expression modulation |
Milestones in the study of this compound class.
Harden and Young identify a heat-stable 'coferment' in yeast extract that accelerates fermentation, the first observation of what became NAD.
Warburg establishes its function as a hydride carrier, placing it at the centre of cellular redox chemistry.
Imai, Armstrong, Kaeberlein and Guarente show Sir2 is an NAD-dependent histone deacetylase, connecting the coenzyme to lifespan control for the first time.
Imai and Guarente describe the NAD+/sirtuin axis as the mechanism translating a cell's energy state into ageing control.
Rajman, Chwalek and Sinclair review the in-vivo evidence for NAD-boosting molecules, moving the field toward clinical study.
Every lot is documented by an independent laboratory. The newest lot appears first.
| Lot | Reported | Size | HPLC | Laboratory | Certificate |
|---|---|---|---|---|---|
| NAD1000-052026-1 | 29 May 2026 | 1000mg | 99.94% | Freedom Diagnostics | View |
| 0FF93Q | 12 May 2026 | 1000mg | 99.97% | Freedom Diagnostics | View |
| 8A0BSG | 12 May 2026 | 500mg | 99.94% | Freedom Diagnostics | View |
| NAD10001225-J | 18 Jan 2026 | 1000mg | 99.936% | Freedom Diagnostics | View |
| NAD12102025-J | 12 Dec 2025 | 500mg | 99.879% | Freedom Diagnostics | View |
| KVPNWJ | 25 Apr 2026 | 500mg | 99.96% | Freedom Diagnostics | View |
| J4Q90F | 25 Apr 2026 | 100mg | 99.85% | Freedom Diagnostics | View |
| VQ8D05 | 25 Apr 2026 | 500mg | 99.40% | Freedom Diagnostics | View |
99.94%
HPLC purity
The signed PDF is the full certificate. The accession and search code above resolve the same record at the laboratory.
HPLC purity
RP-HPLC, 214 nm
Identity
LC-MS
Lot NAD1000-052026-1
This material is supplied as a reference standard for in-vitro laboratory research only. It has not been evaluated by the FDA, is not a drug, and is not intended for human or veterinary use. Handling should follow your institution's chemical hygiene plan, including appropriate PPE and documented disposal.
Every lot is documented at 99%+ by RP-HPLC with identity confirmed by LC-MS, run by an independent laboratory. Released lots have measured between 99.4% and 99.97%; the figure for the lot you receive is in the certificate table above.
Yes. Every lot ships with its own signed certificate, and all eight are published in the COA library, including for lots no longer in stock.
A single 1000mg vial. Certificates on file cover 100mg, 500mg and 1000mg lots from the same production, because the archive records what the laboratory tested rather than only what is currently listed.
It does not have one. NAD+ is not a peptide — it is a dinucleotide coenzyme, two nucleotides joined through their phosphate groups, with no amino acids and therefore no sequence. It sits in this catalogue because it is researched alongside these compounds, not because it shares their chemistry. Identity is confirmed lot-by-lot by LC-MS against a certified reference standard, which is what the certificate reports.
Because the sirtuin enzymes credited with much of the effect of caloric restriction cannot function without it, and because it is consumed rather than recycled in that reaction. That makes its availability a limiting factor, which is the property the literature keeps returning to.
Store the sealed vial at −20°C for long-term stability. It is hygroscopic and light-sensitive, so protect from light and moisture, and avoid repeated freeze-thaw cycles once in solution.
Independent published research relating to this compound. Listed for reference; Serviam Bio Labs is not affiliated with these authors and makes no claims based on their findings.
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai S, Armstrong CM, Kaeberlein M, Guarente L · 2000 · Nature
It takes two to tango: NAD+ and sirtuins in aging/longevity control
Imai S, Guarente L · 2016 · npj Aging and Mechanisms of Disease
NAD+ in aging, metabolism, and neurodegeneration
Verdin E · 2015 · Science
Therapeutic potential of NAD-boosting molecules: the in vivo evidence
Rajman L, Chwalek K, Sinclair DA · 2018 · Cell Metabolism
For laboratory research use only. All compounds listed on this site are sold strictly as reference materials for in-vitro laboratory research conducted by qualified professionals. They are not drugs, foods, cosmetics, or medical devices. They are not intended for human or veterinary consumption, therapeutic use, diagnostic application, or any in-vivo use whatsoever. These statements have not been evaluated by the Food and Drug Administration. By purchasing, you affirm that you are a qualified researcher and that you will comply with all applicable institutional, local, state and federal regulations governing the handling of research chemicals.
